課程資訊
課程名稱
專題討論二
Seminar (Ⅱ) 
開課學期
104-2 
授課對象
生化科技學系  
授課教師
楊啟伸 
課號
BST4001 
課程識別碼
B02 40010 
班次
04 
學分
全/半年
半年 
必/選修
必修 
上課時間
星期二9(16:30~17:20) 
上課地點
農化一第六 
備註
與黃慶璨、張麗冠、陳進庭、林晉玄、吳承合開
總人數上限:20人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1042BST4001_04 
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課程概述

專題討論二 

課程目標
待補 
課程要求
待補 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
待補 
參考書目
待補 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
2/23  課程說明:期刊文章選擇、實驗流程、C123原則檢驗 
第2週
3/01  【學生演講準備週】 
第3週
3/08  【學生演講準備週】 
第4週
3/15  <mark>【林晉玄老師團隊】</mark>
【陳佳妤】<br /> Fusaric acid is a crucial factor in the disturbance of leaf water imbalance in Fusarium-infected banana plants <br /><b><i>Plant Physiology and Biochemistry 60:171-179 (2012)</b></i> 
第5週
3/22  【廖偉廷】<br />Transcriptome profiling of resistant and susceptible cavendish banana roots following inoculation with <i>Fusarium oxysporum f.sp. cubense</i> tropical race 4 <br /><b><i>BMC Genomics 13:374 (2012)</b></i> 
第6週
3/29  【王正緯】<br />Proteomic analysis of conidia germination in Fusarium oxysporum f. sp. cubense tropical race 4 reveals new targets in ergosterol biosynthesis pathway for controlling Fusarium wilt of banana <br /><b><i>Appl Microbiol Biotechnol 99:7189–7207 (2015)</b></i>

【何茂暘】<br />Identification of an endophytic antifungal bacterial strain isolated from the fubber tree and its application in the biological control of banana fusarium wilt <br /><b><i>PLoS ONE 10(7): e0131974</b></i> 
第7週
4/05  (( 放假 )) 
第8週
4/12  <mark>【陳進庭老師團隊】</mark>
【江恆真】
Adaptive Immunity against <i>Streptococcus pyogenes</i> in Adults Involves Increased IFN-γ and IgG3 Responses Compared with Children
<i><b>J Immunol 195: 1657-1664 (2015)</i></b>
 
第9週
4/19  【李宇訢】
Identifying protective <i>Streptococcus pyogenes</i> vaccine antigens recognized by both B and T cells in human adults and children.
<b><i>Scientific Reports 6:22030(2016) </b></i> 
第10週
4/26  <mark>【黃慶璨老師團隊】</mark>
【林映希】<br />Enhanced Efficacy of Therapeutic Cancer Vaccines Produced by Co-Treatment with <i>Mycobacterium tuberculosis</i> Heparin-Binding Hemagglutinin, a Novel TLR4 Agonist
<b><i>Cancer Res 71:2858-2870 (2011)</b></i>.
 
第11週
5/03  【熊浩安】
TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth.
<b><i> PNAS 112:E3216-25 (2015) </b></i>. 
第12週
5/10  <mark>【楊啟伸老師團隊】</mark>
【許哲維】
Boosting BCG-primed mice with chimeric DNA vaccine HG856A induces potent multifunctional T cell responses and enhanced protection against <i>Mycobacterium tuberculosis</i>
<i><b>Immunol Res 64:64–72 (2016)</i></b> 
第13週
5/17  【杜承宏】
Statin Therapy Reduces the <i>Mycobacterium tuberculosis</i> Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation
<i><b>The Journal of infectious Diseases 209(5)(2013)</i></b> 
第14週
5/24  【林宏軒】
The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy
<i><b>Autophagy 10(5):785-802 (2014)</i></b>
【周蔚】
Unique role for ATG5 in neutrophil-mediated immunopathology during <i>M. tuberculosis</i> infection
<i><b>Nature 528:565–569 (2015)</i></b> 
第15週
5/31  <mark>【張麗冠老師團隊】</mark>
【黃斯沛】
Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy
<i><b>Science 351:400-403 (2016)</i></b>
【梁尊傑】
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
<i><b>Human Molecular Genetics, 24:3764–3774 (2015)</i></b>
 
第16週
6/07  【劉子豪】Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. 
第17週
6/14  Final words